Role of Drug resistant mutations in transmission of HIV | Global Events | USA| Europe | Middle East| Asia Pacific

Role of Drug resistant mutations in transmission of HIV

Role of Drug resistant mutations in transmission of HIV Photo

The evolution of resistance is a ubiquitous challenge in antimicrobial chemotherapy.A key driver of resistance is that drug resistance mutations usually persist even in the absence of drugs and despite the fact that resistance mutations are often associated with reduced pathogen replication. Such persistence may occur because fitness costs are low, especially if they are compensated by extra mutations in their “genetic background”. The majority of transmitted drug-resistant viruses contain limited resistance profiles to isolated drug classes. Nucleoside RT inhibitor mutations are the most frequently observed transmitted drug resistance mutations.It is generally acknowledged that most drug resistance mutations decrease the replicative capacity (RC) of HIV-1.

  • Drug resistant pathogens
  • Nucleoside and nucleotide analogue reverse transcriptase inhibitors (NRTIs)
  • Nonnucleoside reverse transcriptase inhibitors (NNRTIs)

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